Developed a capsule endoscope that can be manipulated in vitro

Release date: 2009-07-13




In a significant breakthrough, researchers from Japan’s Ryukoku University and Osaka Medical University have successfully developed a drive device capable of controlling the movement of capsule endoscopes in vitro. Their findings were further validated through successful in vivo experiments, marking an important step forward in the field of medical robotics.

The newly developed system is composed of two main components: first, the generation and control of an alternating magnetic field, and second, a micro-mechanical unit consisting of a small magnet and a "tail." When placed within the magnetic field generated by the first component, the magnet vibrates, causing the tail to move and propel the device forward, much like a fish swims. By adjusting the AC waveform, the speed and direction of the micromachine can be precisely controlled remotely.

This technology allows for external control of capsule endoscopes by integrating the micromechanical unit into the device. The in vivo tests used a small intestine capsule endoscope from Israel-based Given Imaging. The system is designed to be adaptable, as the micromachine can be applied to various capsule endoscopes simply by adjusting the size of the mounting socket.

The given endoscope has an outer diameter of 11 mm and a length of 26 mm. After adding the micromechanical unit, the modified capsule used in the experiment measured 14 mm in diameter and 48 mm in length. For effective movement within the stomach, the capsule needed to be pre-filled with water to allow it to float and maneuver properly.

Experiments were conducted on dogs, confirming three key outcomes: first, the magnetic field did not interfere with image capture or transmission; second, the capsule's movement could be controlled remotely in terms of both speed and direction; and third, the capsule was able to locate and photograph four hemostatic clips placed in the stomach beforehand.

Capsule endoscopy was first introduced in 2001 and gained regulatory approval in Japan in April 2007 for Given Imaging’s small intestine capsule. In September 2008, Olympus Medical Systems also received similar recognition. However, current capsule endoscopes still rely on natural peristalsis for movement, limiting their effectiveness. As a result, the ability to control these devices externally has become a major focus of future research and development in the field. ——Shanghai Medical Device Industry Association

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