British first use artificial sperm to develop mice
London, July 11 — In a groundbreaking study published in the journal *Cell Development*, scientists from the Institute of Biological Stem Cell Research in Durham, Newcastle, UK, have successfully created mice using artificial sperm for the first time. The research, led by Dr. Klimniliya, has opened up new possibilities for treating male infertility and could mark a major step forward in reproductive medicine.
In the experiment, mouse embryos were allowed to develop into blastocysts, after which spermatogonial stem cells were isolated and cultured. These cells were then used to generate functional sperm, which were injected into mouse eggs. The resulting embryos were transferred into the uteruses of female mice, leading to the birth of seven offspring. Although only seven mice were born, the success of this process represents a significant scientific milestone.
However, the efficiency of the procedure remains very low. Out of hundreds of eggs fertilized in this way, only about 50 reached the two-cell stage, and just seven mice were born. One of them died shortly after birth, while the others lived no longer than five months — far below the typical lifespan of two years for normal mice. Dr. Klimniliya emphasized that further research is needed before human trials can begin, but she also stressed that the findings are biologically significant, offering new insights into how life begins and providing a valuable model for future studies.
This isn't the first time scientists have explored the potential of stem cells in reproduction. Researchers at the University of Sheffield previously showed that embryonic stem cells could be used to make sperm, though they did not perform artificial insemination. Meanwhile, scientists in the U.S. and Japan have demonstrated that stem cells can generate mouse eggs and even lead to successful artificial insemination, although no live offspring were produced.
Looking ahead, scientists believe it may one day be possible to create sperm from female stem cells and eggs from male stem cells, enabling same-sex couples to have genetically related children. In theory, even individuals could use their own embryonic stem cells to grow both sperm and eggs for embryo creation. However, such breakthroughs face enormous technical challenges, as most embryos require genetic material from both parents to develop normally.
Despite these hurdles, the recent study proves that viable sperm can be created in the lab, offering hope for new treatments for male infertility. It also raises the possibility of similar solutions for female infertility. In the future, couples struggling with infertility may be able to use lab-grown eggs or sperm to have children with their own genetic traits.
Although the experiment was only partially successful, the researchers see it as a major step forward. It deepens our understanding of sperm development and could help address the global shortage of donor eggs and sperm. One of the most promising approaches involves taking tissue from infertile patients' testes, growing mature sperm in the lab, and then reimplanting them into the body — a method that could revolutionize fertility treatment in the years to come.
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