How to choose a spray dryer suitable for laboratory use

Spray drying is a method in which the system technology is applied to the drying of materials. After the liquid material is atomized in the drying chamber, in the contact with the hot air, the moisture is instantaneously vaporized, that is, the dried product is obtained, and the method can directly make the solution. The emulsion is dried into a powdery or granular product, and the steps of evaporation, pulverization, etc. can be omitted, and the obtained particles are uniformly distributed.

Spray drying has the characteristics of fast heat transfer, rapid evaporation of water, instant drying time, good product quality and good solubility, which can improve the dissolution rate of some preparations. In addition, spray drying can also be used to prepare microcapsules.

“Workers must first sharpen their tools if they want to do their job well”. Researchers may need laboratory sprays of different types for the physical or chemical properties of different materials, as well as the size and solubility of the powder or particles that need to be obtained in the experiment. The dryer can get the best experimental results.

First, high sugar content (if juice, Chinese herbal medicine or natural product extract) or heat sensitive material

Because most of the polysaccharide disaccharides have a relatively low melting point, the sugar melts when heated, and the polysaccharide disaccharide itself is relatively easy to absorb moisture, so ordinary spray dryers are prone to sticking, which is not easy. Get good dry powder or granules.

In addition, like enzyme preparations, live bacteria and some high-molecular materials that are easily denatured at high temperatures, ordinary spray dryers are used, and the materials are easily deactivated or denatured. At this time, the inlet air temperature and air output of the spray dryer are lowered. Temperature, you can get better experimental results, Shanghai Guige Industrial Co., Ltd. GG-6000Y laboratory spray dryer can test at a lower inlet air temperature, for example, the GG-6000Y laboratory spray dryer The temperature can be set from 30 °C to 300 °C, and the general sugar-containing materials can get better particles. The sugar content of some materials may have a lower melting point. At the inlet air temperature of 60-80 ° C, the spray dryer process, such as enzyme preparation, live bacteria, etc., can be instantaneously dried at such a low temperature, and the activity is completely unaffected. .

Second, the solvent is an organic solvent or an easily oxidizable material.

In spray drying, it is difficult to dry the organic solvent. Generally, the organic solvent will be inflammable and explosive. The explosion-proof closed laboratory spray dryer can circulate the material in a closed drying system. The whole system is filled with inert gas. (such as nitrogen or argon), can avoid the contact of organic solvent gas with external oxygen air, ensuring safe production. Shanghai Guige Industrial GG-6000Y experimental organic solvent spray dryer adopts a safe nitrogen (or other inert gas) closed circulation mode. The whole system is completely closed, and the oxygen concentration is monitored online. Once the oxygen concentration in the system reaches 1.5. %, the system will automatically stop and alarm, it is a safe and easy to operate laboratory small organic solvent spray dryer, which can be flammable and toxic by the combination of nitrogen closed circulation and complete solvent recovery. The solvent is treated and the oxidizable material is dried. Further, since the boiling point of the organic solvent is low, it is possible to dry the substance which is susceptible to heat denaturation by a low-temperature drying method.

Third, materials with extremely poor heat sensitivity or improved solubility

Some materials are basically not heated, the traditional freeze-drying time is very long, and the dried materials are in a block shape, the fluidity is poor, and the solubility is not very good.

Compared with traditional freeze drying technology, GG-6000Y laboratory spray freeze dryer has the following advantages:

01. The atomized and dispersed fine droplets are immersed in low temperature and rapidly frozen, which can weaken the growth of ice crystals, reduce the damage of ice crystals to liposomes, and avoid drug leakage and burst release;

02. The frozen sample is vacuum dried to form spherical particles having a microporous structure, and the fluidity is good, and the size of the particles can be adjusted by changing the spraying process. GG-6000Y laboratory spray freeze dryer is suitable for low temperature drying of heat sensitive, viscous, active materials and materials with high sugar content, such as Chinese herbal medicine natural product extract, dairy products, biological preparations, enzyme preparations, fruit juice , polymer materials, etc.

For materials that require direct access to nanomaterials, the GG-6000Y laboratory spray freeze dryer is also an excellent choice.

Fourth, conventional materials

Some laboratories are used for the preparation of conventional powders or for the drying of materials. GG-6000Y laboratory spray dryer can be used. It is small in size, fast in speed, low in noise and easy to operate, and 20ML material can complete an experiment and dry out. The powder has a good sphericity and the particle size is too distributed. In particular, the machine has a spray head water cooling device and a tower wall purging function, which greatly expands the application of the laboratory spray dryer.