The application of avermectin market is huge

As a biopesticide, avermectin has been developing slowly in China, but after five types of highly toxic pesticides were banned, it showed an aggressive development momentum and the dosage was increasing.
In 1975, researchers at the Kitasato Institute in Japan isolated a Streptomyces griseus from soil samples in Shizuoka Prefecture. Subsequently, Merck Corp. of the United States extracted a group of homologues of eight closely related structures from the fermentation mycelium of the strain. The mixed natural product, this is avermectin. In 1981, the company realized the industrialization of avermectin, which was gradually applied in agriculture, animal husbandry and health. In the late 1980s, Shanghai Institute of Pesticides began to develop avermectin. In 1993, China Agricultural University established a project for development. In 1994, it was the first to obtain a temporary registration of 1.8% abamectin EC. At present, there are a total of more than 1400 registered products in the country totaling 1,300, of which 19 are original drug registration companies and the annual production capacity exceeds 900 tons (the original drug). Hebei Weiyuan Biochemical Co., Ltd. is one of the earliest manufacturers of avermectin products in China. It has become the world's largest professional manufacturer and seller of avermectin. The company's avermectin series products account for China and the world respectively. 30% and 25% of the total output.
Abamectin is a new dual-purpose agricultural and livestock antibiotic. It has high biological activity on pests and pests of various crops and is an excellent antibiotic and acaricide. It has a broad spectrum, high efficiency, low residue and human and livestock and environmental safety features. Due to its unique mechanism of action, it can effectively control pests and insect pests that are resistant to commonly used insecticides and acaricides. It is one of the ideal pesticide species for comprehensive prevention and control of agricultural pests. In addition to controlling agricultural pests, avermectin is also widely used in the treatment of a variety of domestic and external parasites of poultry. It is an efficient, broad-spectrum and safe insect repellent for poultry, and it drives both nematodes, insects and mites. Kill activity. At present, the abamectin strains used for pesticide production are mostly natural strains screened from nature. Although some mutations are induced, the expression level of the gene products is limited by the bacterial self-regulatory system and the toxin gene copy number, and still exists. Slow effects, relatively narrow insecticidal spectrum, poor stability, and other constraints.
In the past few years, the abamectin drug market was fiercely competitive and the price dropped again and again. From the beginning of listing, it quickly dropped to 3,000 yuan per kilogram from tens of thousands of kilograms. When it was the lowest in 2003, it dropped to 1,000 yuan per kilogram, resulting in many The company reduced the production of avermectin in 2004. As a result, at the beginning of March 2004, the market was in short supply, the price rebounded sharply, the average price rose to 1,730 yuan/kg, and the market even appeared to have a situation of price and no goods. Many companies were driven by profits and urgently went to Abu The bacteriocin project resulted in a rapid increase in avermectin production. After a price war with chaotic competition, the price of avermectin fell again in 2005, and many companies stopped production due to lower profits. The price of avermectin rose rapidly after the Spring Festival in 2006, and the original drug price reached 1300 yuan/kg, which was double that at the end of 2005. 1.8% avermectin EC, packaging specifications 100 ml / bottle, Zhejiang Qianjiang Biochemical ex-factory price of 60,000 yuan / ton, the market price of 75,500 to 80,000 yuan / ton, and often out of stock.
The relevant personage of Hebei Weiyuan Sinochem believes that avermectin can be widely applied to the control of crop pests such as vegetables, fruit trees, wheat, rice, cotton, and tobacco, and can be used in combination with most pesticides to expand the insecticidal spectrum and improve prevention and treatment Effect and pest killing rate; With the ban of highly toxic pesticides, a large number of downstream products will be developed, the scope of use will be expanded, and the market demand for avermectin will be further expanded.
At present, abamectin, a biological pesticide, has been on the market for more than ten years. Because of its advantages of high efficiency, low toxicity, and high selectivity, it has been favored by the market since its inception and has been widely accepted as a mainstream pesticide by farmers. However, it is precisely this "pampering" has added to the prospect of abamectin also cast a shadow. At the beginning of its existence, avermectin has been safe for humans and livestock under common doses, it has not harmed natural enemies and has not damaged the ecology. It has been well received in the industry and recommended by the Ministry of Agriculture as a pollution-free pesticide. Some media even call it it. "Biological pesticides are wonderful", farmers have used it as a common biological pesticide. Abamectin has a great momentum.
However, Mr. Zhao, who has many years of sales experience in the pesticide industry, told reporters that the product life cycle of abamectin is about to enter the aging period, and its market prospects are not optimistic. Some farmers and vendors have reported that it is difficult to effectively kill pests even if the concentration of medications is continuously increased. According to Mr. Zhao's introduction, the abamectin pesticide had an emulsifiable content of 0.2% when it was first marketed, and it has been developed this year that manufacturers have registered 3% emulsifiable concentrates of emamectin. It is imperative that manufacturers continue to increase their EC content because pests are “increasingly bad” and the root cause is “self-destruction of the Great Wall” because the farmers’ medication level is too low.
Farmers in our country are accustomed to continuously using certain pesticides for many years, and even the best pesticides can not help but use them continuously all the year round. Compared with chemical pesticides, although biological pesticides have low toxicity and strong selectivity, the production of resistance is faster than the former, which is a fatal injury to biological pesticides. Farmers in agricultural advanced countries are relatively scientific in their use of drugs, and they will rarely use the same pesticide continuously for many years. Therefore, the product cycle of pesticides is much longer. On the other hand, the methods used by our country's peasants are also unscientific, and seven to eight pesticides are often used together. Farmers in foreign countries generally only use two types of pesticides. This unscientific use has accelerated the increase of pest resistance to pesticides. At present, the use of avermectin has been greatly reduced in the areas south of the Yangtze River, where pests are very resistant. In northern regions, pests have shown increased resistance. Mr. Zhao believes that this trend will only speed up the elimination of avermectin products.
Mr. Zhao said that this kind of replacement is a normal market phenomenon, because any product has its own product life cycle, and the life cycle of pesticides is more obvious due to biological characteristics. However, the life cycle of products like abamectin should not be so short. If it can be used more scientifically, it can be used as long as foreign pesticides. The avermectin landscape is difficult, reflecting the flaws that high-quality pesticides encounter in front of low-quality applications.
At the same time, experts believe that although industrialized production of avermectin has been achieved at present, there are still problems in selection of strains and high production costs in the industrialization process, which greatly limits the popularization and application of avermectin. Therefore, the next step for the production companies is to develop new varieties, new preparations, and reduce production costs, so as to further open up new space for the abamectin market.

Hōjicha  is a Japanese green tea. It is distinctive from other Japanese green teas because it is roasted in a porcelain pot over charcoal, whereas most Japanese teas are steamed. The tea is fired at a high temperature, altering the leaf color tints from green to reddish brown. The process was first performed in Kyoto, Japan, in the 1920s and its popularity persists today.

Hojicha is often made from bancha ("common tea"),tea from the last harvest of the season; however, other varieties of Hōjicha also exist, including a variety made from sencha, and kukicha, tea made from the twigs of the tea plant rather than the leaves.

Hōjicha infusions have a light- to reddish-brown appearance and are less astringent due to losing catechins during the high-temperature roasting process.The roasted flavors are extracted and dominate this tea: the roasting replaces the vegetative tones of other varieties of Japanese green tea with a toasty, slightly caramel-like flavor. The roasting process used to make Hōjicha also lowers the amount of caffeine in the tea.Because of its mildness, Hōjicha is a popular tea to serve during the evening meal or after, before going to sleep, and even preferred for children and the elderly.

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