The latest research progress of melamine in infant formula
According to the ScienceDirect database, in March 2013, Food and Chemical Toxicology published an article on the latest research on melamine in infant formula, citing the analysis of chemistry and toxicity of melamine in infant formula. Recent advances in science, epidemiology, exposure, risk assessment, and current regulations.
According to the World Health Organization, the daily allowable intake of melamine is 0.2 mg/kg bw/d. Current melamine detection methods include: enzyme-linked immunosorbent assay, high performance liquid chromatography, capillary electrophoresis, gas chromatography-tandem mass spectrometry. , liquid chromatography-tandem mass spectrometry. The melamine level test program provides a basis for laboratory certification and validation of melamine test methods.
The latest human metabolism studies show that melamine is mainly distributed in blood and extracellular fluid, and a small amount is distributed in tissues and organs. Renal histopathology and clinical diagnostic studies have shown that melamine forms a melamine-uric acid complex precipitate in the lower urinary tract leading to obstructive kidney stones. Epidemiological studies have shown that large and sustained intake of melamine may cause kidney stones. The review pointed out that there is still a lack of further research on the prevalence and chronic hazards of melamine-induced nephrotoxic diseases.
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