New insights into HIV vaccines will promote the development of this vaccine
Release date: 2013-01-17
Four years ago, a promising HIV vaccine showed its potential to fight HIV, but the fly in the ointment is that it does not have a broad protective effect on the spread of AIDS. Now, a new study led by Duke University School of Medicine, the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, the US Military AIDS Research Program, and the Thai Ministry of Health has made new research on the role of HIV vaccines. Insights, their findings help explain why the vaccine can only benefit one-third of the vaccinators, while others are still vulnerable to HIV infection. The results, published in the January 10, 2013 issue of Immunity, provide a new option for vaccine designers to enhance the effectiveness of the drug. Dr. Barton Haynes, a senior researcher at the project, is the director of the Human Vaccine Institute at Duke University. He said: "This study clarifies what types of antibodies are induced by vaccines and provides us with guidance for future vaccine trials. Information. An in-depth understanding of how this vaccine works is important for developing ways to enhance their effectiveness.†The team focused on a vaccine candidate called “ALVAC†that was tested in Thailand. In 2009, AIDS researchers reported that the vaccine protected 31. 2% of subjects from HIV infection. This protection rate sounds very encouraging, but it is still less than the 50% required to slow the AIDS epidemic. AIDS has afflicted some 34 million people in the world. Since then, researchers have been studying the vaccine to try to find out the reasons that affect its success in order to make improvements. Haynes and his colleagues published an article last year that stated that they found a link between a key antibody that responded to the vaccine and a reduced risk of infection. Haynes said: "But that's just a link between the vaccine and the risk of infection. It's not a link to vaccine protection. We can't prove that this antibody is a factor influencing vaccine protection." In this new study Researchers have increased their understanding of the links between vaccine-inducible antibodies and identified key features of these vaccine-inducible antibodies. They analyzed the immune response of three subjects who were vaccinated in the initial trial and isolated four key antibodies to the V2 region, an important region of the HIV virus. Despite the large variability in the structure of the viral V2 locus, these antibodies recognize the virus, especially at a site that binds to the outer envelope protein of the virus, and we already know that this site will attract immunity. Warrior" - neutralizing antibodies. The results of the study indicate that these types of V2 antibodies can expand the arsenal of the immune system against HIV and may enhance the epidemic prevention of existing ALVAC vaccines. Dr. Hua-Xin Liao, the author of the article and director of research at the Human Vaccine Institute at Duke University, said: "Our next step is to explore how to design immunogens to induce antibodies with broad neutralizing activity. Our findings for this A study provides new targets."
Source: Medical Xpress
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