The pharmacological effects of Zhu Lik
Pharmacological effects
1. Antitussive effect: Cizhu lek 30ml/kg, 5ml/kg gavage, can significantly extend the mouse ammonia stimulate half of the effective cough spray time (EDT50), respectively, the control group of 226%, 186%, stronger than The same dose of light bamboo Lek.
2. Cockroach effect: The trachea phenol red method confirmed that the mice were orally administered with 5 ml/kg and 15 ml/kg. 30ml/kg Cizhu Lie had obvious scorpion effect. In the range of 5-30ml/kg dose, the dose-effect relationship was not obvious.
3. Anti-asthmatic effect: Cizhu Le 10ml/kg gavage, 2 times a day, for 3 consecutive days can significantly reduce the incidence of grade IV asthma caused by 0.5% phosphoryl histamine spray in guinea pigs, prolong the latency of asthma, the effect is stronger than light bamboo Lek.
4. Effects on mice's small intestine movement: Cizhu lek 5ml/kg, 15ml/kg, 30ml/kg gavage, has the effect of promoting small intestine movement in mice, and there is significant difference in high-dose group.
5. Toxicity: Cizhu Lixue was administered twice to the stomach with 50 ml/kg each time and 4 times within 24 hours (the total dose was 400 ml/kg). There was no abnormal reaction in mice.
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