Japanese experts use genetically modified rice to develop anti-allergic rice

Japanese scientists discovered after experimenting with mice that an oral vaccine obtained using genetically modified rice prevented allergic immune responses. The immune response to pollen was reduced in mice that consumed this vaccine, and the frequency of sneezing was much lower than that of the control group that did not consume the vaccine. The results of this research are published in the online edition of the Journal of the National Academy of Sciences. Immunotherapy, commonly known as anti-allergic needles, has long been one of the treatment options for certain allergic diseases.
The main subject of the new study, Dr. Gao Yan, said that compared with anti-allergic needles, edible vaccine plants will have several advantages, the most obvious of which is that they will not cause pain. He and his colleagues developed their vaccine using certain allergenic protein particles found in Japanese cedar pollen, which is a common cause of hay pollen in Japan. They added the genetic material of these proteins to the rice genome to produce rice containing pollen proteins. Later, they asked a group of mice to eat this kind of vaccine rice every day, and let them contact Japanese cedar pollen for several weeks. The researchers found that compared with mice that did not eat this kind of rice, the former’s immune response to pollen was greatly reduced, not only the secretion of histamine (a chemical that causes hay fever symptoms) was reduced, but also sneezing was not so frequent.
Dr. Gao Yan is a researcher at the National Institute of Agricultural and Biological Sciences in Japan. He said that he and his colleagues have developed vaccine-type rice suitable for humans and they are planning to undergo safety tests in the next few years.

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