Pfizer finds new ideas for treating blood cancer: let cancer cells have nowhere to hide
For blood cancers such as acute myeloid leukemia (AML), most methods attack the cancer cells themselves. Now, Pfizer scientists have found a way to get cancer cells out of hiding and make them more vulnerable.
AML is a hematological malignancy caused by abnormal proliferation of myeloid hematopoietic cells. The rapid proliferation of these cells affects the production of normal hematopoietic cells. As the most common acute leukemia in adults, the incidence of AML increases with the age of the person, but the cure rate decreases. According to the data in The New England Journal of Medicine, the cure rate is about 35%-40% in people under 60 years of age. However, once the onset age is over 60 years old, the cure rate is reduced to 5%-15%, and the average survival rate of the elderly who cannot afford strong chemotherapy is 5-10 months. Therefore, these patients are in urgent need of new treatments.
In malignant tumors, the highly expressed chemokine receptor CXCR4, upon binding to its ligand CXCL12, triggers an intracellular signaling pathway that controls the transfer of cells into tissues such as bone marrow. In blood cancer, the protective mechanism of CXCR4-driven bone marrow on malignant cells is the key to the development of the disease and making it difficult to treat. Based on this pathway, Pfizer developed a humanized CXCR4 antibody called PF-06747143, which is expected to bind CXCR4 and inhibit CXCL12-mediated signaling and cell migration. Therefore, this new drug is expected to allow AML cells to leave the bone marrow and enter the bloodstream, which is attacked by other effective therapies. In addition, PF-06747143 is also expected to induce tumor cell death through its Fc constant region-mediated effector function.
Pfizer's work on the new drug PF-06747143 (Source: ScienceDaily)
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