Be alert to artificial light pollution! Brightness can lead to premature aging

Be alert to artificial light pollution! Brightness can lead to premature aging

August 15, 2016 Source: Bio Valley

Eliane Lucassen, a researcher at the Leiden University Medical Center in the Netherlands, works night shifts and starts working at 6 pm every day. However, her research team recently discovered that an abnormal schedule may cause her to have health problems. This seems to sound very funny, but the researchers say that this is actually unhealthy.

Researchers Eliane Lucassen and Johanna Meijer recently published in the journal Current Biology that continuous light can severely damage the circadian clock and trigger a range of health problems that promote premature aging in mice; mice exposed to persistent glare Experienced the process of loss of bone density, skeletal muscle degeneration and inflammation, and turning off the light can restore their health problems. This research is only an initial study, and researchers believe that people living in artificial light environments may also Face similar risks.

Interference mode

Researchers say that now we all know that smoking is harmful, or that eating sugar is harmful, but we never think that light is harmful to us. Previous studies in animals and human organisms have revealed the association between artificial light exposure and health problems. Epidemiological analysis found that workers with jet lag may have breast cancer, metabolic syndrome, and osteoporosis. The risk is higher; and exposure to strong light at night may increase the risk of cardiovascular disease in individuals, which usually does not allow the individual to have adequate sleep.

However, it may be difficult to reveal the direct correlation between light exposure and health problems. The researcher Meijer controls the body's biological clock by implanting electrodes in the animal's brain to determine the activity of neurons in the animal's brain. The relationship was followed by the researchers placing the mice in a cage full of light for up to 24 hours. Animals use some cushioning materials to build their nests, they can move freely, and when they are asleep, their eyes are tightly closed, but the sleeping mice can't avoid the influence of light, and they will get about seven points in awake state. The level of light exposure, in general, is often exposed to more light conditions than in an environment with a light-dark cycle.

As a result, the pattern of neuronal activity in the mouse brain changes, causing the cells to be in an irregular pulsed pacing zone, and the loss of synchronized images often occurs in the aging brain of the animal. In the article, the researchers found that when the mouse takes 25.5 hours of circadian clock every day, the body's bone density will be lost, and the muscles will decline. At the same time, the researchers also measured the strength of the mice to control the forelimbs; when the researchers recovered the dark environment After that, the neurons in the mouse brain will return to the normal rhythm, and the circadian clock will also turn to 24 hours a day.

Bright, big influence

Richard Stevens, a researcher at the University of Connecticut School of Medicine, who has been working on the effects of light on cancer, said that we used an innovative analytical method to study the circadian rhythm of the mouse's body and found that the results may not be Applicable to the human body, the glare applied to the mouse may be more glaring than the light-dark cycle (even under extreme conditions) experienced by humans in the real environment.

In the next experiment we should use 12 hours of light, 6 hours of dark light and 6 hours of dark environment to study, which may be more similar to the lighting environment experienced by humans; researchers believe that merely disturbing the clock can not promote The health effects reported in the article, and the poor quality of sleep and the light itself do affect the health of the body, so we probably should not blame too much on the changes in the circadian clock. Meijer said that this study should remind people who are in intensive care and night shifts to pay more attention.

An artificial light pollution map released in June pointed out that two-thirds of the world's population is affected by light pollution, and last month the American Association of Scientific and Public Health Medical Association called for reducing artificial light pollution, the researchers said. Bright artificial light can increase the risk of cancer, diabetes, and cardiovascular and cerebrovascular diseases in individuals. Next, the researcher Meijer plans to study how light affects the body's immune system. The researchers wanted to study the repeated neuronal monitoring in the grass rats, not like the laboratory mice. It was very active during the day and the researchers were also very interested in studying the circadian clock of the prairie rats.

Researchers say that later, they will use more in-depth research to explore why light accelerates the aging of mice. Researchers hope that the results of the mouse research can be applied to the human body, never effectively preventing and developing treatment-specific New treatments for disease provide new ideas and research clues.

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